首页>
外国专利>
COMPOSITIONS AND METHODS FOR IDENTIFYING SUBJECTS WHO MAY BENEFIT FROM TREATMENT WITH THERAPEUTIC AGENTS
COMPOSITIONS AND METHODS FOR IDENTIFYING SUBJECTS WHO MAY BENEFIT FROM TREATMENT WITH THERAPEUTIC AGENTS
展开▼
机译:鉴定可从治疗剂中受益的对象的组合物和方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present application relates to compositions and methods for the identification of subjects who are likely to benefit from use of a therapeutic agent. The present invention utilizes the specificity of therapeutic monoclonal antibodies for a single epitope to determine whether a therapeutic monoclonal antibody interacts with biological material in/from a patient. The targeting complex comprises 1. antibody A, wherein antibody A is a potential therapeutic monoclonal antibody, or fragment thereof, comprising (a) a variable region specific to an epitope of interest, and (b) a human constant region; and 2. antibody B, wherein antibody B recognizes the human constant region of antibody A.
展开▼