DIAGNOSTIC BIOMARKERS FOR DETECTING, SUBTYPING, AND/OR ASSESSING PROGRESSION OF MULTIPLE SCLEROSIS

摘要

Disclosed are methods, compositions and kits for detecting Multiple Sclerosis (MS) as well as for distinguishing relapsing-remitting (RRMS) and secondary progressive (SPMS) MS subtypes with high overall accuracy. Autoantibody antigens and biomarkers, for the diagnosis of MS in general, RRMS and SPMS, as well as for the identification of a subject at risk for developing MS, and for the generation of patient-specific MS autoantibody biomarker profiles are also provided.