APPLICATIONS OF TRIPTOLIDE AND DERIVATIVE THEREOF IN PREPARING MEDICAMENT FOR TREATING AND/OR PREVENTING LUNG-DAMAGING DISEASES

摘要

Provided in the present invention is a novel use of triptolide and of a derivative thereof. Triptolide can significantly inhibit elevation effects of GFP fluorescent protein and of P24 antigen in a phorbol ester-activated lymphocyte model, the higher the concentration of triptolide, the lower the percentage of GFP positive cells and the concentration of P24 antigen; hence, a negative dose-effect relation is present. Even when methylprednisolone is at a concentration as high as 400 uM, the inhibitory effects of same is not as good as that of triptolide at a concentration of 0.02 uM, while the ratio of apoptosis significantly exceeds that of triptolide at a concentration of 0.02 uM. The principle is such that triptolide inhibits G0/G1 phase cell ratio elevation and S phase cell ratio reduction caused by PMA, promotes a cell cycle to remain in an unactivated state; triptolide provides the effect of inhibiting lymphocyte proliferation and activation by regulating cell cycle and, at the same time, also provides the effect of inhibiting virus replication. The triptolide and the derivative thereof of the present invention can be used in place of or jointly with a glucocorticoid analogue for use in treating and/or preventing lung-damaging diseases.