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THEACRINE-BASED SUPPLEMENT AND METHOD OF USE THEREOF IN A SYNERGISTIC COMBINATION WITH CAFFEINE
THEACRINE-BASED SUPPLEMENT AND METHOD OF USE THEREOF IN A SYNERGISTIC COMBINATION WITH CAFFEINE
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机译:基于茶氨酸的补充剂及其在与咖啡因的协同组合中的使用方法
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摘要
A human dietary supplement comprises theacrine and optionally other compounds that modulate the effects of theacrine. Uses for the theacrine-containing supplement include improvement of at least one of mood, energy, focus, concentration or sexual desire or a reduction of at least one of anxiety or fatigue. A synergistic composition comprises co-administration of theacrine and caffeine, wherein the co-administered caffeine reduces theacrine oral clearance (CL/F) and oral volume of distribution (Vd/F). In addition, the co-administered caffeine increases area under the plasma concentration time curve (AUC) of theacrine, and increases theacrine maximum plasma concentration (Cmax) in comparison with the corresponding pharmacokinetic parameters when theacrine is administered alone.
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机译:人的膳食补充剂包含茶碱和任选地调节茶碱作用的其他化合物。含茶碱的补充剂的用途包括改善情绪,精力,注意力,注意力或性欲中的至少一种或减少焦虑或疲劳中的至少一种。协同组合物包含茶碱和咖啡因的共同给药,其中所述共同给药的咖啡因降低茶碱的口服清除率(CL / F)和口服分布体积(Vd / F)。此外,与咖啡因一起使用时,与咖啡因一起使用时,咖啡因的共同使用增加了茶碱的血浆浓度时间曲线(AUC)下的面积,并增加了茶碱的最大血浆浓度(C max Sub>)。单独。
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