首页> 外国专利> A HIGH-THROUGHPUT (HTP) GENOMIC ENGINEERING PLATFORM FOR IMPROVING SACCHAROPOLYSPORA SPINOSA

A HIGH-THROUGHPUT (HTP) GENOMIC ENGINEERING PLATFORM FOR IMPROVING SACCHAROPOLYSPORA SPINOSA

机译：改善糖蔗孢子菌的高通量基因工程平台

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摘要

The present disclosure provides a HTP microbial genomic engineering platform for Saccharopolyspora spp. that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols. This integrative platform utilizes a suite of HTP molecular tool sets to create HTP genetic design libraries, which are derived from, inter alia, scientific insight and iterative pattern recognition.

机译：本公开提供了用于糖多孢菌属的HTP微生物基因组工程平台。它是由计算驱动的，并集成了分子生物学，自动化和高级机器学习协议。该集成平台利用一套HTP分子工具集来创建HTP遗传设计库，该库尤其来自科学见解和迭代模式识别。 展开▼

著录项

公开/公告号WO2018226893A3

专利类型

公开/公告日2019-01-10

原文格式PDF

申请/专利权人 ZYMERGEN INC.;
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申请/专利号WO2018US36352

发明设计人 MASON BENJAMIN;GORANOV ALEXI;KELLY PETER;KIM YOUNGNYUN;MODI SHEETAL;PASUMARTHI NIHAL;MIJTS BENJAMIN;ENYEART PETER;
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申请日2018-06-06

分类号C12N15/10;

国家 WO

入库时间 2022-08-21 11:57:47

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3. A HIGH-THROUGHPUT (HTP) GENOMIC ENGINEERING PLATFORM FOR IMPROVING SACCHAROPOLYSPORA SPINOSA [P] . 欧洲知识产权局专利： EP3635110A2 . 2020-04-15

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5. A HIGH-THROUGHPUT (HTP) GENOMIC ENGINEERING PLATFORM FOR IMPROVING SACCHAROPOLYSPORA SPINOSA [P] . CA3064619A1 . 2018-12-13

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1. Selection of Reference Genes in Saccharopolyspora Spinosa for Real-Time PCR [J] . 张传波, 薛超友, 申月琪, 天津大学学报（英文版） . 2015,第005期

2. Multi-omics-data-assisted genomic feature markers preselection improves the accuracy of genomic prediction [J] . Shaopan Ye, Jiaqi Li, Zhe Zhang 畜牧与生物技术杂志：英文版 . 2021,第002期

3. Multi-omics-data-assisted genomic feature markers preselection improves the accuracy of genomic prediction [J] . Shaopan Ye, Jiaqi Li, Zhe Zhang 畜牧与生物技术杂志(英文版) . 2021,第002期

4. First SPA-based Platform for High-throughput Drug Screening Established in China [J] . 中国科学院院刊（英文版） . 2003,第004期

5. A high-throughput screening method for breeding Aspergillus niger with 12C6+ ion beam-improved cellulase [J] . Bo-Ling Jiang, Fu-Qiang Xu, Shu-Yang Wang, 核技术（英文版） . 2017,第001期

6. Characterization of the chromosomal integration of Saccharopolyspora plasmid pCM32 and its application to improve production of spinosyn in Saccharopolyspora spinosa [J] . Chen Jian, Xia Haiyang, Dang Fujun, Applied Microbiology and Biotechnology . 2015,第23期

7. Metabolic Engineering of Rational Screened Saccharopolyspora spinosa for the Enhancement of Spinosyns A and D Production [J] . Amit Kumar Jha, Anaya Raj Pokhrel, Amit Kumar Chaudhary, Molecules and cells . 2014,第10期

8. Stepwise increase of spinosad production in Saccharopolyspora spinosa by metabolic engineering [J] . Chaoyou Xue, Yuejiao Duan, Fanglong Zhao Biochemical Engineering Journal . 2013,第Null期

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10. Uses for High-Throughput Platforms and Big Data in Engineering and Learning Biological Systems [D] . Soh, Lemuel M. 2018

11. Metabolic Engineering of Rational Screened Saccharopolyspora spinosa for the Enhancement of Spinosyns A and D Production [O] . Amit Kumar Jha, Anaya Raj Pokhrel, Amit Kumar Chaudhary, 2014

12. Comparative genomics and transcriptional profiles of Saccharopolyspora erythraea NRRL 2338 and a classically improved erythromycin over-producing strain [O] . Clelia Peano, Adelfia Tala, Giorgio Corti, 2012

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