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THIENOPYRANONES AND FURANOPYRANONES AS CHECKPOINT INHIBITORS AND MODULATIORS OF ANTI-TUMOR IMMUNITY
THIENOPYRANONES AND FURANOPYRANONES AS CHECKPOINT INHIBITORS AND MODULATIORS OF ANTI-TUMOR IMMUNITY
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机译:噻吩并呋喃酮作为检查点的抑制剂和抗肿瘤免疫调节剂
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摘要
The invention relates to methods of treating diseases including but not limited to, cancer, non-cancer proliferative disease, sepsis, autoimmune disease, viral, bacterial or fungal infection, atherosclerosis, Type 1 or 2 diabetes, obesity, inflammatory disease, and/or SYK-associated disorder including by modulating biological processes through the inhibition of SYK alone, or in combination with inhibition of one or more of PI3 kinase including PI3K-gamma isoform, BET bromodomain proteins, CDK 4/6, and checkpoint proteins, comprising the administration of a compound(s) of Formula I-V (or pharmaceutically acceptable salts thereof) as defined herein.
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