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TUMOUR-TARGETED NANOCAPSULE, PREPARATION METHOD THEREFOR AND USE THEREOF
TUMOUR-TARGETED NANOCAPSULE, PREPARATION METHOD THEREFOR AND USE THEREOF
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机译:肿瘤靶向纳米胶囊,制备方法及其用途
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摘要
Disclosed is a tumour-targeted nanocapsule comprising a polymer sensitive to a tumour microenvironment, a substance having an anti-tumour activity and encapsulated by the polymer, and a tumour diagnostic reagent or a contrast agent; wherein the polymer sensitive to the tumour microenvironment comprises a cross-linking agent sensitive to the tumour microenvironment and 2-methacryloyloxyethyl phosphorylcholine, and the cross-linking agent sensitive to the tumour microenvironment at least comprises a polypeptide cross-linking agent capable of being degraded by an enzyme overexpressed in the tumour microenvironment. The polypeptide cross-linking agent capable of being degraded by an enzyme overexpressed in the tumour microenvironment is preferably one or more of a polypeptide cross-linking agent capable of being degraded by matrix metalloproteinases and a polypeptide cross-linking agent capable of being degraded by hyaluronidases, and is more preferably one or more of a polypeptide cross-linking agent capable of being degraded by matrix metalloproteinases.
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