首页> 外国专利> A PERIPHERALLY-RESTRICTED DUAL-ACTING KAPPA AND DELTA OPIOID AGONIST FOR ANALGESIA IN PAIN STATES INVOLVING THE INFLAMMATORY RESPONSE

A PERIPHERALLY-RESTRICTED DUAL-ACTING KAPPA AND DELTA OPIOID AGONIST FOR ANALGESIA IN PAIN STATES INVOLVING THE INFLAMMATORY RESPONSE

机译：疼痛状态涉及痛觉反应的痛觉双重镇静性 KAPPA 和 DELTA 阿片类药物

展开▼

页面导航

摘要

著录项

相似文献

摘要

The present disclosure teaches the use of a dual-acting opioid agonist for the treatment of pain (e.g., inflammatory pain). The opioid agonist activates both the kappa and delta opioid receptors to provide synergistic reduction in pain. The opioid agonist is peripherally restricted and does not cross the blood-brain barrier. 展开▼

机译：本公开教导了双作用阿片样物质激动剂在治疗疼痛（例如炎性疼痛）中的用途。阿片类激动剂可激活 kappa 和 delta 阿片类受体，从而协同减轻疼痛。阿片样物质激动剂在外周受限制并且不穿过血脑屏障。 展开▼

著录项

公开/公告号WO2019010014A1

专利类型

公开/公告日2019-01-10

原文格式PDF

申请/专利权人 CAVENTURE DRUG DISCOVERY INC.;
展开▼

申请/专利号WO2018US38936

发明设计人 HARTRICK CRAIG;
展开▼

申请日2018-06-22

分类号C07D491;

国家 WO

入库时间 2022-08-21 11:57:23

相似文献

专利

外文文献

中文文献

1. 瑞马唑仑在制备治疗阿片类药物诱发的术后痛觉过敏的药物中的应用 [P] . 中国专利： CN112402428B . 2022.02.25

2. 瑞马唑仑治疗阿片类药物诱发的术后痛觉过敏中的应用 [P] . 中国专利： CN112402428A . 2021-02-26

3. Peripherally-restricted dual-acting kappa and delta opioid agonist for analgesia in pain states involving the inflammatory response [P] . US11185551B2 . 2021-11-30

机译：外围限制的双代理Kappa和Delta阿片类Agonist用于涉及炎症反应的痛苦状态

4. A peripherally-restricted dual-acting kappa and delta opioid agonist for analgesia in pain states involving the inflammatory response [P] . IL271772D0 . 2020-02-27

机译：一种外周限制性双作用κ和δ阿片样物质激动剂，用于疼痛状态下的炎症反应镇痛

5. A PERIPHERALLY-RESTRICTED DUAL-ACTING KAPPA AND DELTA OPIOID AGONIST FOR ANALGESIA IN PAIN STATES INVOLVING THE INFLAMMATORY RESPONSE [P] . SG11201912036XA . 2020-01-30

机译：疼痛状态涉及炎症反应的痛觉抑制的永久性双作用Kappa和δ阿片类药物

1. Effects of ketamine combined with lidocaine for preemptive analgesia on postoperative pain, inflammatory response and stress response in patients with cervical cancer [J] . Xin-Sheng Chen, Yun-Xia Rao 海南医科大学学报（英文版） . 2018,第008期

2. Effects of ketamine combined with lidocaine for preemptive analgesia on postoperative pain, inflammatory response and stress response in patients with cervical cancer [J] . Xin-Sheng Chen, Yun-Xia Rao 海南医科大学学报(英文版) . 2018,第008期

3. Effects of Preemptive Analgesia with Flurbiprofen Axetil Injection on Analgesia, Inflammatory Response, Stress Response and Immune Response in Patients Undergoing Thoracoscopic Lobectomy [J] . LI Na, WANG Fen-li, ZOU Ming-shan 中国生物医学工程学报（英文版） . 2019,第002期

4. Reversal of Mechanical Hyperalgesia by a Dual-Acting, Peripherally-Restricted Kappa/Delta Opioid Agonist (CA1001) in a Rat Model of Inflammatory Arthritis [J] . Hartrick C., Molenaar R., Hartrick A., The journal of pain: official journal of the American Pain Society . 2019,第4Suppla1期

5. The Efficacy of a Dual-Acting, Peripherally-Restricted Kappa/Delta Opioid Agonist (CA1001) in Neuropathic Pain in the Rat [J] . Hartrick C., Van Valkenburg T., Kartrick A., The journal of pain: official journal of the American Pain Society . 2019,第4Suppla1期

6. Peripherally-Restricted Dual-Acting Kappa/Delta Opioid Agonist (CA1001) Prevents Formalin-Induced Hyperalgesia [J] . Hartrick C., Poulin D., Hartrick A. The journal of pain: official journal of the American Pain Society . 2019,第4Suppla1期

7. Identification of opioid receptor ligand interactions using structurally related delta-opioid receptor agonists and antagonists and molecular modeling. [C] . Sharon D.Bryant, Yunden Jinsmaa, Lawrence H.Lazarus International Peptide Symposium;European Peptide Symposium . 2005

8. Promoting peripheral opioid analgesia: The role of interactions between mu- and delta-opioid receptor agonists. [D] . Schramm, Cicely L. 2010

9. Dual-Acting Peripherally Restricted Delta/Kappa Opioid (CAV1001) Produces Antinociception in Animal Models of Sub-Acute and Chronic Pain [O] . Craig T Hartrick, Dominic Poulin, Rebekka Molenaar, 2020

10. Diuretic Activity of a Novel Peripherally-Restricted Orally-Active Kappa Opioid Receptor Agonist [O] . Tyler C. Beck, Matthew A. Hapstack, Gautam S. Ghatnekar, 2019

1. DN-9: a multifunctional agonist of opioid and neuropeptide FF receptors that produces nontoleranceforming analgesia via peripheral opioid receptors in inflammatory and neuropathic pain models [J] . XU Biao ,ZHANG Meng-na ,SHI Xue-rui . 中国药理学与毒理学杂志 . 2018,第9期

2. Effects of mu and kappa opioid receptor agonists and antagonists on contraction of isolated colon strips of rats with cathartic colon [J] . Bao-HuaLiu PingMo Sheng-BenZhang . 世界胃肠病学杂志：英文版 . 2004,第11期

3. 阿片类药物诱导痛觉增敏的机制 [C] . 季丙元 ,陈京 ,白波 . 第十九次全国行为医学学术会议 . 2017

4. 神经病理性痛及阿片类药物引起的痛觉过敏导致大鼠脑疼痛通路改变的功能磁共振研究 [A] . 周文昌 . 2019