NEW COMPOUNDS DERIVED FROM PYRIDINE METHYL SULFINYL BENZOXAZOLES AND PYRIDINE METHYL SULFINYL BENZOTHIAZOLES, TAGGED RADIOACTIVELY OR FLUORESCENTLY, AND COMPOSITIONS THEREOF AS SPECIFIC BIOMARKERS FOR THE DIAGNOSIS OF NEURODEGENERATIVE DISEASES AND PATHOLOGIES INVOLVING TAU PROTEIN

摘要

The present invention relates to pyridine methyl sulfinyl benzoxazole compounds and pyridine methyl sulfinyl benzothiazole compounds, tagged radioactively or fluorescently, and compositions thereof, as specific biomarkers for the diagnosis of neurodegenerative diseases and pathologies involving tau protein, such as Alzheimer's and other dementias. According to the present invention, the techniques in which the described molecules can be used include: computerised axial tomography (CAT); nuclear magnetic resonance (NMR), both structural NMR (sNMR) and functional NMR (fNMR); single-photon emission computed tomography (SPECT); and positron-emission tomography (PET). Thus, the invention provides a pharmacologically safe tool with high affinity and selectivity for protein structures of tau protein, which allows an application, method or use of said agents to be established for the identification and diagnosis of neurodegenerative diseases, tau pathologies, preferably Alzheimer's disease.