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PEPTIDE TARGETING MYCOBACTERIUMTUBERCULOSIS TOXIN-ANTITOXIN SYSTEM AND USE THEREOF

机译：肽靶向分枝杆菌 结核杆菌毒素-抗毒素系统及其用途

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摘要

The present invention relates to a peptide targeting a toxin-antitoxin system of Mycobacteriumtuberculosis and a use thereof. Specifically, the antibiotic peptide of the present invention inhibits the formation of a toxin-antitoxin complex of Mycobacteriumtuberculosis without affecting an active site of the toxin, thereby inducing the death of Mycobacteriumtuberculosis by means of a separated toxin. Therefore, the antibiotic peptide can be usefully used as an antibiotic composition against Mycobacteriumtuberculosis. 展开▼

机译：本发明涉及靶向结核分枝杆菌的毒素-抗毒素系统的肽及其用途。具体而言，本发明的抗生素肽抑制分枝杆菌结核的毒素-抗毒素复合物的形成，而不影响毒素的活性位点，从而导致的死亡。 I>分枝杆菌结核通过分离的毒素。因此，该抗生素肽可以有效地用作抗分枝杆菌 结核的抗生素组合物。 展开▼

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公开/公告号WO2019027224A3

专利类型

公开/公告日2019-03-21

原文格式PDF

申请/专利权人 SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION;
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申请/专利号WO2018KR08680

发明设计人 LEE BONG-JIN;KANG SUNG-MIN;KIM DO-HEE;
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申请日2018-07-31

分类号C07K7/08;A61K38;

国家 WO

入库时间 2022-08-21 11:56:50

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