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- Antituberculosis peptides increasing toxicities of endogenous toxin and targeting toxin-antitoxin system of Mycobacterium tuberculosis and use thereof

机译：-增加结核分枝杆菌的内源性毒素的毒性并靶向毒素-抗毒素系统的抗结核肽及其用途

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摘要

The present invention relates to an anti-tuberculosis peptide that increases the toxicity of endogenous toxins of Mycobacterium tuberculosis and targets the toxin-antitoxin system and its use. Specifically, the anti-tuberculosis peptide of the present invention is an RNA degradation of Mycobacterium tuberculosis toxin protein MazF4. Increasing activity and inhibiting the formation of MazEF4, a toxin-antitoxin complex of Mycobacterium tuberculosis, induces the killing of Mycobacterium tuberculosis. Therefore, the anti-tuberculosis peptide can be usefully used as an antibiotic composition against Mycobacterium tuberculosis.

机译：本发明涉及一种抗结核肽，其可增加结核分枝杆菌的内源性毒素的毒性并靶向该毒素-抗毒素系统及其用途。具体地，本发明的抗结核肽是结核分枝杆菌毒素蛋白MazF4的RNA降解。增加活性并抑制结核分枝杆菌的毒素-抗毒素复合物MazEF4的形成，可以诱导杀死结核分枝杆菌。因此，抗结核肽可用作抗结核分枝杆菌的抗生素组合物。 展开▼

著录项

公开/公告号KR102083398B1

专利类型

公开/公告日2020-03-02

原文格式PDF

申请/专利权人 서울대학교산학협력단;
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申请/专利号KR20180083660

发明设计人 이봉진;안도환;
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申请日2018-07-18

分类号C07K7/06;A61P31/06;

国家 KR

入库时间 2022-08-21 11:05:14

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