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CANCER MARKER GENES FOR P53-NON MUTATIONAL CANCER, AND THERAPEUTIC AGENT SCREENING METHOD
CANCER MARKER GENES FOR P53-NON MUTATIONAL CANCER, AND THERAPEUTIC AGENT SCREENING METHOD
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机译:P53非突变型癌症的癌基因和治疗剂筛选方法
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摘要
The present invention relates to cancer marker genes for p53-non mutational cancer, and a therapeutic agent screening method. Although mutations of tumor suppressor gene p53 have been found in most cancers thus far, the screening method of the present invention, based on p53-upstream regulatory genes, for independently regulating the over-expression of MDM2, having clearly been investigated for the first time by the present applicant, enables p53-non mutational cancer-specific anticancer agents to be effectively screened for. In addition, the genes investigated in the present invention (see table 1) are significantly up-regulated in a p53-non mutational cancer state, thereby enabling the occurrence of p53-non mutational cancer to be diagnosed whereas conventional cancer diagnosis has been dependent on the existence of p53 mutations.
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