EUTECTIC OF TELMISARTAN AND HYDROCHLOROTHIAZIDE

摘要

Disclosed are a eutectic of telmisartan and hydrochlorothiazide, a preparation method therefor and the use thereof. In the eutectic, the molar ratio of telmisartan to hydrochlorothiazide is 1:1. The eutectic of telmisartan and hydrochlorothiazide is fully characterized by X-ray single crystal diffraction analysis, H nuclear magnetic resonance spectroscopy, thermogravimetric analysis, differential scanning calorimetry, infrared spectrum analysis and other means, and it is found that the maximum blood concentration of the eutectic in SD rats is higher than that of both hydrochlorothiazide and telmisartan. The eutectic of telmisartan and hydrochlorothiazide has a simple preparation method and good physical and chemical properties.