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TARGETED EPIGENETIC THERAPY FOR INHERITED AORTIC ANEURYSM CONDITION
TARGETED EPIGENETIC THERAPY FOR INHERITED AORTIC ANEURYSM CONDITION
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机译:遗传性主动脉瘤病的靶向表皮治疗
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摘要
Transforming growth factor β (TGFβ) transcriptional responses are involved in the pathogenesis of aortic aneurism syndromes. Compositions that inhibit histone acetyltransferase activity normalize gene expression in the aorta, preserved aortic wall architecture and abrogated aneurism progression. Methods include the use of these compositions to epigenetically regulate abnormal expression and/or activity of TGFβ genes.
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