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SYNERGISTIC COMBINATION OF IL4 RECEPTOR TARGETED AGENTS, INTERFERON GAMMA, AND INTERFERON ALPHA FOR USE IN TREATING OVARIAN CANCER
SYNERGISTIC COMBINATION OF IL4 RECEPTOR TARGETED AGENTS, INTERFERON GAMMA, AND INTERFERON ALPHA FOR USE IN TREATING OVARIAN CANCER
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机译:IL4受体靶向剂,干扰素γ和干扰素α的协同组合用于治疗卵巢癌
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摘要
Methods and compositions are disclosed for treating a subject with a cancer. The compositions can include a chimeric molecule comprising an agent that specifically binds the interleukin 4 receptor (IL-4R) and a toxic moiety, an interferon alpha (IFNa), and an interferon gamma (IFNy). In some non-liming embodiments, the compositions can also include monocytes. The methods disclosed herein include administering a therapeutically effective amount of the compositions taught herein to a subject with cancer, thereby treating the cancer in the subject, wherein cells in the cancer express IL-4R. In some non-liming embodiments, the methods can also include administering monocytes.
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