Methods and systems for monitoring bacterial ecosystems and providing decision support for antibiotic use

摘要

The present disclosure provides computer-implemented methods for annotating a query nucleic acid sequence. Methods of the present disclosure provide for the accurate annotation of nucleic acid sequences having functional or other important implications. Subject methods also provide for generating an assembly for longer DNA sequences that comprise shorter annotated sequences. Also provided are methods for monitoring the genetic material within a defined physical location. Such methods may find use in a variety of applications, for example, monitoring the spread of a pandemic, monitoring the prevalence of antibiotic resistance, provide guidance in making clinical decisions, and others. Also provided are related systems and non-transitory computer- readable recording media.