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Aziridine containing epothilone analogs, methods of synthesis, methods of treatment, and drug conjugates
Aziridine containing epothilone analogs, methods of synthesis, methods of treatment, and drug conjugates
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机译:含氮丙啶的埃坡霉素类似物,合成方法,治疗方法和药物结合物
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摘要
In one aspect, the present disclosure provides epothilone analogs of the formula: (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, drug conjugates with cell targeting moieties of the compounds are also provided.
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