CHIMERIC ANTIGEN RECEPTORS AND BISPECIFIC ANTIBODIES FOR TREATMENT OF MANTLE CELL LYMPHOMA

摘要

Provided herein are, inter alia, compositions and methods for the treatment of cancer. The compositions include, for example, a chimeric antigen receptor or a bispecific antibody comprising a free immunoglobulin light chain VL, inter alia, useful for targeting and killing human mantel cell lymphoma (MCL) cells. Due to their ability to differentially bind MCL cells versus non-cancer cells, the compositions provided herein may be used, for example, for therapeutic and diagnostic purposes.