COMPOSITIONS AND METHODS FOR TREATING AR-AND/OR LNCRNA-MEDIATED DISEASES

摘要

The present invention is based, at least in part, on the discovery that androgen receptor (AR) interacts with long non-coding RNA (IncRNA) in a sequence-specific manner, and that single-stranded nucleic acids designed to sterically block the interaction between AR and such IncRNA without significantly altering the expression of AR and/or Inc RNA can be applied to effectively modulate the activity of AR or IncRNA.