Acetate salt of buprenorphine and methods for preparing buprenorphine

摘要

#$%^&*AU2019203308A120190530.pdf#####ABSTRACT OF THE DISCLOSURE The present disclosure provides acetate salts of buprenorphine, and its anhydrates, solvates, hydrates, and crystalline forms thereof, where the acetate salts of buprenorphine are essentially free of impurities. The disclosure further provides method of preparing the acetate salts, buprenorphine 5 free base prepared from the acetate salts, other salts prepared from the free base, and pharmaceutical compositions thereof essentially free of impurities.