ACETATE SALT OF BUPRENORPHINE AND METHODS FOR PREPARING BUPRENORPHINE

摘要

To provide buprenorphine containing acceptable levels of impurities.SOLUTION: The present disclosure provides acetate salts of buprenorphine, and its anhydrates, solvates, hydrates and crystalline forms thereof. The present disclosure further provides method of preparing the acetate salts, buprenorphine free bases prepared from the acetate salts, other salts prepared from the free bases, and pharmaceutical compositions thereof, essentially free of impurities.SELECTED DRAWING: Figure 1