COMPOSITION FOR TRANSCATHETER ARTERIAL CHEMOEMBOLIZATION, COMPRISING NANOPARTICLE FOR ANTICANCER THERAPY AND GENE THERAPY

摘要

The present invention relates to a nanoparticle that comprises a gene therapy-enabling siRNA hydrogel containing an anticancer agent-impregnated nanoparticle and an embolic material therein and which can be used in chemoembolization and perform both gene therapy and drug therapy, and a composition comprising the same. Designed to comprise an siRNA hydrogel core containing a drug therein, a medium layer of cationic chitosan surrounding the core, and an outer layer of anionic hyaluronic acid, the present invention can release siRNA and the drug for a long period of time and thus shows very long sustainability of a medicinal effect. A composition for transcatheter arterial chemoembolization, comprising the nanoparticle according to the present invention can exert chemoembolization and drug therapy and effectively regulate the expression of a target gene, thereby increasing anticancer therapeutic effect. The nanoparticle of the present invention is coated with hyaluronic acid having (-) charges and thus can be effectively delivered into cells through the CD44 receptor expressed on liver cancer cells, bringing about a maximum effect on gene therapy and anticancer therapy.