METHOD FOR DIAGNOSING HEAD AND NECK CANCER VIA BACTERIAL METAGENOMIC ANALYSIS

摘要

The present invention relates to a method for diagnosing head and neck cancer via bacterial metagenomic analysis and, more particularly, to a method for diagnosing head and neck cancer by performing bacterial metagenomic analysis by means of samples derived from a normal person and a subject and analyzing variations in the contents of extracellular vesicles derived from certain bacteria. Extracellular vesicles secreted from bacteria that are present in the environment may cause chronic inflammation locally, or be absorbed into a body and have a direct influence on carcinogenesis, and head and neck cancer is difficult to diagnose at an early stage prior to the appearance of symptoms thereof and thus makes efficient treatment difficult. The metagenomic analysis of extracellular vesicles, derived from bacteria, using samples derived from human bodies, according to the present invention, allows prediction of the incidence risk of head and neck cancer, thus allows early diagnosis and prediction of a head and neck cancer risk group and can delay the time of onset or prevent the occurrence of the disease through appropriate management, and also can lower the incidence rate of head and neck cancer and increase the effect of treatment by enabling early diagnosis after the onset.