Method for diagnosing gastric cancer by bacterial metagenomic analysis

摘要

The present invention relates to a method of providing information for gastric cancer diagnosis through bacterial metagenomic analysis, more particularly, a method of predicting a risk for gastric cancer or diagnosing gastric cancer by analyzing an increase or decrease in content of extracellular vesicles derived from specific bacteria through bacterial metagenomic analysis of genomes present in extracellular vesicles isolated from a subject-derived sample. Extracellular vesicles secreted from bacteria existing in the environment are absorbed into the human body, and thus may directly affect the occurrence of cancer, and gastric cancer has a very high incidence rate and a very high mortality rate in Korea, and thus prevention and early diagnosis thereof through prediction of the onset thereof is very important. Thus, according to the present invention, gastric cancer may be predicted through bacterial metagenomic analysis of extracellular vesicles present in a human body-derived sample, which leads to early diagnosis and prediction of a high risk group for gastric cancer, and, accordingly, the onset of gastric cancer may be delayed or gastric cancer may be prevented through appropriate management, and, even after gastric cancer occurs, early diagnosis for gastric cancer may be implemented, thereby lowering the onset of gastric cancer and increasing therapeutic effects. In addition, patients diagnosed with gastric cancer are able to avoid exposure to causative factors, whereby the progression of gastric cancer may be ameliorated, or recurrence of gastric cancer may be prevented.