首页> 外国专利> CEREBLON PROTEIN DEGRADATION INDUCING COMPOUND, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER, CONTAINING SAME AS ACTIVE INGREDIENT

CEREBLON PROTEIN DEGRADATION INDUCING COMPOUND, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER, CONTAINING SAME AS ACTIVE INGREDIENT

机译:血浆脑蛋白降解复合物,其制备方法及预防或治疗癌症的药物成分,包含与有效成分相同的成分

摘要

The present invention relates to a cereblon protein degradation inducing compound, a preparation method therefor and a pharmaceutical composition for preventing or treating cancer, containing the same as an active ingredient. A novel compound represented by A-Linker-A or A-Linker-B, according to the present invention, can remarkably inhibit or degrade cereblon, and thus, by containing the same as an active ingredient, the present invention is useful as a pharmaceutical composition for preventing or treating cereblon-related diseases, preferably diseases, such as cancer, autoimmune diseases or metabolic diseases, in which effects such as treatment, prevention or alleviation can be achieved by inhibiting or degrading cereblon.
机译:本发明涉及一种脑神经蛋白质降解诱导化合物,其制备方法和用于预防或治疗癌症的药物组合物,其含有该化合物作为活性成分。根据本发明,由A-连接基-A或A-连接基-B代表的新型化合物可以显着抑制或降解脑神经,因此,通过包含其作为活性成分,本发明可用作药物。用于预防或治疗与大脑相关的疾病的组合物,优选疾病如癌症,自身免疫性疾病或代谢性疾病,其中可以通过抑制或降解大脑来达到治疗,预防或缓解的作用。

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