CHIMERIC ANTIGEN RECEPTOR, NK CELL MODIFIED BY SAME, CODING DNA, MRNA, EXPRESSION VECTOR, PREPARATION METHOD AND APPLICATION

摘要

Provided are a chimeric antigen receptor, an NK cell modified by same, a coding DNA, an mRNA, an expression vector, a preparation method and application. The chimeric antigen receptor comprises an antigen binding structural domain, a silent region, a transmembrane domain and an intracellular structural domain which are operatably connected and sequentially connected to each other in series. The antigen binding structural domain is from an NKG2D ligand binding domain, and the intracellular structural domain is from a DAP12 intracellular signal area.