The present disclosure relates to recombinant single chain fragment variable (ScFv) binding to DEC-205 of dendritic cells having amino acid sequence selected from a group consisting of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, and SEQ ID NO: 9. Also disclosed are ScFv-antigen complex, a method for inducing immune response in a subject using the ScFv-antigen complex and a vaccine composition comprising the ScFv-antigen complex. The ScFv-antigen complex as disclosed herein can be used as immuno-contraceptives for mammals.
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机译：本公开涉及与树突细胞的DEC-205结合的重组单链片段变量（ScFv），所述树突细胞具有选自SEQ ID NO：1，SEQ ID NO：2，SEQ ID NO：3，SEQ ID NO：4，SEQ ID NO：5，SEQ ID NO：6，SEQ ID NO：7，SEQ ID NO：8和SEQ ID NO：9。还公开了ScFv-抗原复合物，一种诱导免疫应答的方法。在受试者中使用ScFv-抗原复合物和包含ScFv-抗原复合物的疫苗组合物。如本文公开的ScFv-抗原复合物可用作哺乳动物的免疫避孕药。
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