Disclosed is a method for preparing florfenicol intermediate V, which belongs to the technical field of the preparation of veterinary medicines. The method comprises an addition reaction, a ring-closing reaction, a hydrolysis reaction and a ring-opening reaction. Further disclosed is a method for preparing florfenicol by further subjecting florfenicol intermediate V to a reduction reaction, a cyclization reaction, a fluoridation reaction and a ring-opening reaction subsequent to the preparation of florfenicol intermediate V. In the method for preparing florfenicol intermediate V, these reaction steps can be continuously operated, the process is simple, the route is concise and short, and the chiral purity and yield of the product are high; and in the method for preparing florfenicol by using intermediate V, waste water pollution and a resolution process are avoided, the utilization rate of atoms in the reactions is increased, the cost is reduced, and the process is simplified.
展开▼
