ORAL GASTRORETENTIVE SUSTAINED-RELEASE PHARMACEUTICAL FORMULATION

摘要

The present invention provides a gastroretentive pharmaceutical composition for oral administration with sustained release comprising at least one active ingredient effective in stomach (preferably rebamipide), which further comprises at least one pharmaceutically acceptable auxiliary substance capable of swelling the pharmaceutical composition to density below 1 g/cm3 at pH between 1.5 and 3.5, at least one pharmaceutically acceptable auxiliary substance capable of ensuring sustained release of the active ingredient, and at least one pharmaceutically acceptable component capable of forming carbon dioxide upon contact with gastric juices. The pharmaceutical composition can be prepared by dry or wet granulation and/or dry homogenization of the active ingredient with the auxiliary substances and components.