POLYMORPHIC FORMS OF (9-(R)-2-(S)-(S)-1- (ISOPROPOXYCARBONYL)ETHYLAMINOPHENOXY PHOSPHINYLMETHOXYPROPYL ADENINE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF

摘要

The present invention discloses novel crystalline polymorphic forms of (9-[(R)-2-[[(S)-[[(S)-1- (isopropoxy carbonyl) ethyl] amino] phenoxyphosphinyl] methoxy]propyl] adenine hemifumarate and 9-[(R)-2-[[(S)-[[(S)-1- (isopropoxycarbonyl)ethyl] amino]phenoxy phosphinyl]methoxy]propyl] adenine monofumarate, methods of preparation, pharmaceutical compositions and methods of therapeutic treatment involving polymorphic forms thereof.