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LONG-ACTING AND LOW-TOXIC RECOMBINANT ANTI-VEGF HUMANIZED MONOCLONAL ANTIBODY AND PRODUCTION METHOD THEREFOR
LONG-ACTING AND LOW-TOXIC RECOMBINANT ANTI-VEGF HUMANIZED MONOCLONAL ANTIBODY AND PRODUCTION METHOD THEREFOR
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机译:长效低毒重组抗人血管内皮生长因子单克隆抗体及其生产方法
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摘要
The present invention relates to a full length humanized monoclonal antibody that can specifically bind to VEGF. The antibody can inhibit binding of VEGF to VEGFR-1 and VEGFR-2, thereby inhibiting signaling of VEGF. The antibody has a strong affinity for VEGF, has a long half-life, and is highly safe after vitreous injection. The antibody of the invention may be effective in treating diseases associated with VEGF overexpression, particularly diseases associated with abnormal angiogenesis caused by VEGF overexpression.
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