CHIMERIC ANTIGEN RECEPTORS CONTAINING OPTIMAL SPACER REGION

摘要

The present invention relates to a Chimeric Antigen Receptor(CAR)containing a spacer having an optimal structure that generates an improvement of the antitumor effect of the molecule.Particularly, the CAR according to the present invention carries a spacer domain consisting of a fragment of the human low affinity nerve growth factor receptor (LNGFR) composed by a first sequence including the four TNFR-Cys domains, linked to a second sequence consisting of the first 11 amino acids of the serine/threonine rich stalk.