Chimeric Antigen Receptors (CARs) Having Mutations in the Fc Spacer Region and Methods For Their Use

摘要

#$%^&*AU2020204351A120200716.pdf#####ABSTRACT Adoptive immunotherapy using T cells genetically redirected via expression of chimeric antigen receptors (CARs) is a promising approach for cancer treatment. However, this immunotherapy is dependent in part on the optimal molecular design of the CAR, which involves an extracellular ligand-binding domain connected to an intracellular signaling domain by spacer and/or transmembrane sequences.