METHODS OF TREATING MYOCARDITIS AND/OR CARDIOMYOPATHY AND REAGENTS THEREFOR

摘要

The present disclosure is directed to methods and reagents for treatment or prevention of myocarditis and/or cardiomyopathy. For example, the method and reagents of the disclosure may be useful for treating or preventing cardiac hypertrophy and/or preventing cardiac fibrosis and/or improving cardiac function in a subject suffering from cardiomyopathy. In particular, the present disclosure relates to the use of an isolated or recombinant antibody or antigen binding fragment thereof, which binds to the N-terminal domain of midkine (MK) protein, and inhibits or reduces the function of MK in the treatment or prevention of myocarditis and/or cardiomyopathy.