NOVEL CRYSTALLINE FORM OF BARICITINIB PHOSPHATE AND PREPARATION METHOD THEREOF

摘要

The present invention relates to the field of pharmaceutical chemistry, and provides a novel crystalline form of baricitinib phosphate and a preparation method thereof. The crystalline form is crystalline form α or crystalline form β. An XRPD spectrum of the crystalline form α comprises characteristic peaks at the following 2θ (the error is ±0.2º) values: 12.45, 14.65, 15.47, 16.34, 17.47, 20.45, 22.07, 24.22, 25.58, 26.64, 28.50, and 29.86º. An XRPD spectrum of the crystalline form β comprises characteristic peaks at the following 2θ (the error is ±0.2º) values: 3.84, 8.17, 12.76, 16.84, 19.05, 21.85, and 24.73º. Both the crystalline form α and the crystalline form β have good solubility or stability, are beneficial to operations in storage, transfer, and production processes, and are suitable for being prepared into preparations.