MODULATORS OF C1Q, IN PARTICULAR OF THE INTERACTION OF APOE WITH C1Q, AND USES OF THE MODULATORS IN THE THERAPY OF NEURONAL DISEASES AND INFLAMMATION

摘要

The present invention relates to modulators of complex 1 protein q (C1q) that preferably mimic and/or stabilize the interaction of inhibitor apolipoprotein-E (ApoE) with C1q, and their uses in the prevention or treatment of C1q-related diseases or conditions, such Alzheimer's disease (AD), atherosclerosis, kidney diseases, and ageing.