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USE OF FERRUGININ A (FGA) COMPOUND AS A CHEMOTHERAPEUTIC GENT AND MAPK PATHWAY INHIBITOR DUE TO BIOLOGICAL ACTIVITY THEREOF
USE OF FERRUGININ A (FGA) COMPOUND AS A CHEMOTHERAPEUTIC GENT AND MAPK PATHWAY INHIBITOR DUE TO BIOLOGICAL ACTIVITY THEREOF
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机译:由于其生物活性,将铁蛋白A(FGA)用作化学治疗剂和MAPK通路抑制剂
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摘要
The invention relates to use ferruginin A (FGA) compound that presents an effective cytotoxic activity in cancer chemotherapy as an anticancer agent and MAPK pathway inhibitor. The objective of the invention is to use Ferruginin A (FGA) compound that can be isolated from the bark of Harungana madagascariensis, as an anticancer agent and as MAPK pathway inhibitor at MCF-7 cells. The fact that Ferruginin A presents low effect on human normal skin fibroblasts, thus presents selective toxicity towards the cancer cells selective toxicity is exploited under the scope of the invention.
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