NANOPARTICLE FORMULATION FOR ORAL INSULIN DELIVERY, AND PREPARATION METHOD THEREFOR

摘要

A nanoparticle formulation for oral insulin delivery, and a preparation method therefor. Said nanoparticles have a core-shell structure, wherein said core is a nanocomposite core consisting of a chitosan quaternary ammonium salt and an insulin, and said shell is a hyaluronic acid or a thiolated hyaluronic acid coated on the surface of said core. The preparation method therefor comprises: preparing said insulin-loaded nanoparticles by applying an FNC technology, and coating the surface of said nanoparticles with said hyaluronic acid.