DRUG FOR CHRONIC INFLAMMATORY DISEASE AND METHOD FOR EVALUATING SUSCEPTIBILITY TO CHRONIC INFLAMMATORY DISEASE

摘要

[Problem] The purpose of the present invention is to provide new treatment targets and treatment methods for chronic inflammatory disease based on a molecular biological mechanism relating to the onset of keloid. [Solution] The present invention relates to a drug for the prevention and/or treatment of chronic inflammatory disease that contains as an active ingredient a substance that suppresses the expression and/or inhibits the activity of a specific NEDD4 splicing variant protein. Also provided are a method for evaluating the susceptibility of a subject to chronic inflammatory disease and a method for evaluating the suitability of treatment of a chronic inflammatory disease by the abovementioned drug that include a step for detecting the NEDD4 splicing variant protein or mRNA in a collected tissue, a drug for preventing and/or treating chronic inflammatory disease that contains as an active ingredient a substance that suppresses the expression and/or inhibits the activity of NEDD4 protein, and a method for evaluating the susceptibility of a subject to chronic inflammatory disease that includes a step for detecting a specific SNP of NEDD4.