STEM CELL PREPARATION RESISTING HYPOXIA INJURY, PREPARATION METHOD THEREFOR, AND USE THEREOF IN PREPARATION OF MEDICAMENT FOR TREATING ACUTE MYOCARDIAL INFARCTION

摘要

A stem cell preparation resisting hypoxia injury, a preparation method therefor, and use thereof in preparation of a medicament for treating acute myocardial infarction. The preparation method for the stem cell preparation resisting hypoxia injury comprises mixing stem cells and a liquid of lentivirus with Fstl1 overexpression in a medium to obtain the stem cell preparation resisting hypoxia injury. The Fstl1 modified MSCs provided by the present invention have anti-hypoxia injury capability, can improve transplant survival rate, and can improve the cardiac function after infarction by means of direct injection into the cardiac muscle.