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N-METHYL-D-ASPARTIC ACID RECEPTOR MODULATORS

机译:N-甲基-D-丙二酸受体调节剂

摘要

A series of subunit selective allosteric modulators of NMDA receptor function according to Formula (I) is provided herein. Also provided is a method of treating neurological disorders such as Alzheimer's disease Parkinson's disease, schizophrenia, depression, stroke, psychosis and the like using compounds of Formula (I), optionally in combination with one or more further active agent. Pharmaceutical compositions containing a compound of Formula (I) and optionally one or more active agent for treating such disorders may be provided in the form of a tablet, capsule, pill, gel, granules, aerosol, aqueous buffer or a nanoparticle formulation, emulsion, liposome, etc. (I)
机译:本文提供了根据式(I)的一系列NMDA受体功能的亚基选择性变构调节剂。还提供了使用式(I)的化合物,任选地与一种或多种其他活性剂组合,治疗神经系统疾病例如阿尔茨海默氏病,帕金森氏病,精神分裂症,抑郁症,中风,精神病等的方法。可以以片剂,胶囊剂,丸剂,凝胶剂,颗粒剂,气雾剂,水性缓冲剂或纳米颗粒制剂,乳剂,药物制剂的形式提供包含式(I)化合物和任选地一种或多种用于治疗此类疾病的活性剂的药物组合物,脂质体等(I)

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