Subcellular distribution of N-methyl-D-aspartic acid receptor subunit 1 in neural stem cells within subventricular zone of adult rats

摘要

The subcellular localization of N-methyl-D-aspartic acid receptor subunit 1 in neural stem cells of the subventricular zone of adult rats was detected using electron microscopy,following immunohistochemistry and immunogold-silver double staining.Results confirmed the presence of neural stem cells in the subventricular zone,which is a key neurogenic region in the central nervous system of adult mammals.The expression of N-methyl-D-aspartic acid receptor subunit 1 was higher than that of nestin and mainly distributed in the cell membrane,cytoplasm,rough endoplasmic reticulum and Golgi complex of neural stem cells.