PREVENTING EXON 7 AND/OR EXON 8 INCLUSION INTO AN AMYLOID PRECURSOR PROTEIN (APP) MRNA

摘要

The invention relates to neurodegenerative disorders, and in particular to novel oligonucleotides for treating such conditions, for example Alzheimer's disease. The invention provides novel antisense oligonucleotides, and compositions comprising such oligos, and therapies and methods for treating neurodegenerative disorders. The invention includes genome editing techniques for achieving similar results as using the novel antisense oligonucleotides.