首页>
外国专利>
MULTIFUNCTIONAL MOLECULES THAT BIND TO CALRETICULIN AND USES THEREOF
MULTIFUNCTIONAL MOLECULES THAT BIND TO CALRETICULIN AND USES THEREOF
展开▼
机译:钙网蛋白结合的多功能分子及其用途
展开▼
页面导航
摘要
著录项
相似文献
摘要
Multifunctional molecules that include i) an antigen binding domain that binds to a calreticulin mutant protein; and one, two or all of: (ii) an immune cell engager (e.g., chosen from an NK cell engager, a T cell engager, a B cell engager, a dendritic cell engager, or a macrophage cell engager); (iii) a cytokine molecule or a modulator of a cytokine molecule; and/or (iv) a stromal modifying moiety are disclosed. Additionally disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, and methods of treating a cancer using the aforesaid molecules.
展开▼