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DYNAMICALLY CONCENTRATING ION PACKETS IN THE EXTRACTION REGION OF A TOF MASS ANALYZER
DYNAMICALLY CONCENTRATING ION PACKETS IN THE EXTRACTION REGION OF A TOF MASS ANALYZER
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机译:TOF质量分析仪提取区域中的动态浓缩离子袋
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摘要
Systems and methods are disclosed for dynamically switching an ion guide and a TOF mass analyzer between concentrating or not concentrating ions in a targeted acquisition. Product ions are ejected from the ion guide into the TOF mass analyzer and the intensity of a known product ion is measured at two or more time steps. The ion guide initially ejects product ions using a sequential or Zeno pulsing mode that concentrates product ions with different m/z values within the TOF mass analyzer at the same time. If the intensity of the product ion is increasing and greater than a threshold intensity, the ion guide switches to a continuous or normal pulsing mode that does not concentrate ions with different m/z values in the TOF mass analyzer at the same time. Similarly, if the intensity decreases below a threshold in continuous mode, the ion guide switches back to sequential mode.
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