REPROGRAMMING CD4 T CELLS INTO CYTOTOXIC CD8 CELLS BY FORCED EXPRESSION OF CD8AB AND CLASS 1 RESTRICTED T CELL RECEPTORS

摘要

Embodiments of the disclosure include methods and compositions related to improvements of T cell therapy. In particular embodiments, CD8+ T cell therapy is enhanced upon expression of transgenic Ε08αβ co-receptor in the CD8+ T cells. In certain embodiments, CD4+ T cells are rendered to have cytotoxic cell function for adoptive transfer upon expression of transgenic Ε08αβ co-receptor in the CD4+ T cells. In specific embodiments, TCR- expressing and Ε08αβ co-receptor-expressing CD4+ and CD8+ T cells are utilized in adoptive transfer.