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METHODS TO INDUCE TERMINAL DIFFERENTIATION IN STEM CELLS BY INTERFERING WITH DNA REPLICATION, METHODS OF INDUCING PANCREATIC DIFFERENTIATION, AND DIFFERENTIATED CELLS OBTAINED THEREOF
METHODS TO INDUCE TERMINAL DIFFERENTIATION IN STEM CELLS BY INTERFERING WITH DNA REPLICATION, METHODS OF INDUCING PANCREATIC DIFFERENTIATION, AND DIFFERENTIATED CELLS OBTAINED THEREOF
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机译:通过干扰DNA复制在干细胞中诱导终末分化的方法,诱导胰腺分化的方法以及获得其的分化细胞
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摘要
The current invention provides for methods and systems of inducing cell cycle exit and terminal differentiation in stem cells undergoing differentiation into various mature cell types in particular pancreatic endocrine cells. The current invention also provides for methods and systems of inducing differentiation of pancreatic endocrine cells from stem cells. The invention also provides for the cells produced by the methods that are suitable for transplantation or grafting into a subject for the prevention and/or treatment of disease, and useful for basic research and drug testing.
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