Composition for preventing improving or treating of fibrosis comprising jellyfish venom as effective component

摘要

The present invention relates to a composition for preventing, ameliorating or treating fibrosis, which comprises a jellyfish toxin as an active ingredient, wherein the jellyfish toxin of the present invention is α-smooth muscle actin (α-SMA), which is known to be mainly expressed upon induction of fibrosis, (Matrix metalloproteinase-1) or MMP-13 (matrix metalloproteinase-13), collagen-I (collagen-Ⅰ) or vimentin, and TGF-β1 / Smad signaling In addition, it induces apoptosis and cell cycle arrest of fibrosis-induced cells by treatment with TGF-β1, thereby exhibiting an anti-fibrosis effect.