The present invention relates to a multisubstituted 4H -thiazolo [4,5- e ] [1,4] diazepine-5,8-dione derivative represented by the general formula (1) and an HMGB1 protein activity- To their use in vascular inflammation related infectious diseases. The multisubstituted 4 H -thiazolo [4,5- e ] [1,4] diazepine-5,8-dione derivatives of the present invention were found to have anti-septic effects through CLP-induced sepsis, By increasing the survival rate, it has been found that the above-mentioned polysubstituted 4H -thiazolo [4,5- e ] [1,4] diazepine-5,8-dione derivative or a pharmaceutically acceptable salt thereof is used as an active ingredient And can be usefully used as a therapeutic agent for vascular inflammatory diseases and infectious diseases including sepsis induced by HMGB1 protein activity.
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机译：本发明涉及由通式（I）表示的多取代的 4H -噻唑洛[4,5- e ] [1,4]二氮杂-5,8-二酮衍生物。 1）和HMGB1蛋白活性-用于血管炎相关的感染性疾病。发现本发明的多取代的4 H -噻唑洛[4,5- e ] [1,4]二氮杂-5,8-二酮衍生物具有抗-通过CLP引起的败血症引起的败血症作用，通过提高存活率，发现上述多取代的 4H -thiazolo [4,5- e ] [1 ，4]二氮杂5，8-二酮衍生物或其药学上可接受的盐用作活性成分，并且可以有效地用作血管炎性疾病和包括由HMGB1蛋白活性诱导的败血症在内的传染性疾病的治疗剂。
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