首页>
外国专利>
Beta-hairpin peptide mimetics with elastase inhibitory activity and their aerosol dosage forms
Beta-hairpin peptide mimetics with elastase inhibitory activity and their aerosol dosage forms
展开▼
机译:具有弹性蛋白酶抑制活性的β-发夹肽模拟物及其气溶胶剂型
展开▼
页面导航
摘要
著录项
相似文献
摘要
The invention has the inhibitory activity to human neutrophil elastase (neutrophil elastase), the formula cyclo (-OctG-Glu-Thr-Ala -Ser-Ile-Pro-Pro-Gln-Lys-Tyr- D Pro-Pro - ) peptidomimetic, or a pharmaceutically acceptable salt thereof. The present invention further relates to solid or liquid pharmaceutical compositions, and kits for the manufacture and administration of such aerosols. The present invention also relates to a pharmaceutical composition for the treatment of pulmonary diseases mediated by or caused by human neutrophil elastase activity such as alpha-1 antitrypsin deficiency (AATD), cystic fibrosis (CF), non-cystic fibrosis bronchiectasis (NCFB) , Or chronic obstructive pulmonary disease (COPD), or lung infection or disease, or condition. Thus, the present invention also relates to the use of an active compound: cyclo (-OctG-Glu-Glu-Glu-Glu-Glu- Thr-Ala-Ser-Ile-Pro-Pro-Gln-Lys-Tyr- D Pro-Pro-) or a pharmaceutically acceptable salt thereof.
展开▼
机译:本发明对人嗜中性粒细胞弹性蛋白酶(neutrophil elastase)具有抑制活性,分子式为环(-OctG-Glu-Thr-Ala-Ser-Ile-Pro-Pro-Gln-Lys-Tyr-D Pro-Pro->)拟肽或其药学上可接受的盐。本发明进一步涉及固体或液体药物组合物,以及用于制造和施用这种气雾剂的试剂盒。本发明还涉及用于治疗由人类嗜中性粒细胞弹性蛋白酶活性介导或引起的肺部疾病的药物组合物,例如α-1抗胰蛋白酶缺乏症(AATD),囊性纤维化(CF),非囊性纤维化支气管扩张(NCFB),或慢性阻塞性肺疾病(COPD),或肺部感染或疾病或状况。因此,本发明还涉及活性化合物的用途:环(-OctG-Glu-Glu-Glu-Glu-Glu-Thr-Ala-Ser-Ile-Pro-Pro-Gln-Lys-Tyr- D Sup> Pro-Pro-)或其药学上可接受的盐。
展开▼